Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond

Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).

Deregulation of ER-mitochondria contact formation and

Pten heterozygosity restores neuronal morphology in fragile X

Structural Modulation of Dendritic Spines during Synaptic

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FMRP and the Pathophysiology of Fragile X Syndrome - ScienceDirect

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PDF) Fragile X syndrome: Are signaling lipids the missing culprits?

mRNA Localization: An Orchestration of Assembly, Traffic and