Safe Combinations - Dishonored 2 Guide - IGN

You can find a number of safes with various kinds of loot within each mission. Its a good idea to unlock any safes you come across since you can find

Dishonored: Kaldwins Bridge Rune Inside Safe (Location and Combo)

Safe Combinations - Dishonored: Death of the Outsider Guide - IGN

Dishonored 2, Addermire Institute

Safe Combinations - Dishonored: Death of the Outsider Guide - IGN

Safe Contest Combination, Dishonored Wiki

Safe Combinations - Dishonored: Death of the Outsider Guide - IGN

Safe Combinations - Dishonored 2 Guide - IGN

Safe Combinations - Dishonored 2 Guide - IGN

Imperial Signet Ring, Dishonored Wiki